0000001 - Document - Cover link:presentationLink link:calculationLink link:definitionLink 0000002 - Document - Audit Information link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - Consolidated Statements of Operations link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - Consolidated Statements of Operations (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - Consolidated Statements of Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 9952156 - Statement - Consolidated Statements of Changes in Convertible Preferred Stock and Stockholders’ Equity link:presentationLink link:calculationLink link:definitionLink 9952157 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 9952158 - Disclosure - The Company and Basis of Presentation link:presentationLink link:calculationLink link:definitionLink 9952159 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 9952160 - Disclosure - Fair Value Measurements link:presentationLink link:calculationLink link:definitionLink 9952161 - Disclosure - Cash Equivalents and Marketable Securities link:presentationLink link:calculationLink link:definitionLink 9952162 - Disclosure - Property and Equipment, Net link:presentationLink link:calculationLink link:definitionLink 9952163 - Disclosure - Accrued and Other Current Liabilities link:presentationLink link:calculationLink link:definitionLink 9952164 - Disclosure - Asset Acquisition link:presentationLink link:calculationLink link:definitionLink 9952165 - Disclosure - Paragon Agreement link:presentationLink link:calculationLink link:definitionLink 9952166 - Disclosure - Licensing Agreements link:presentationLink link:calculationLink link:definitionLink 9952167 - Disclosure - Related Party Transactions link:presentationLink link:calculationLink link:definitionLink 9952168 - Disclosure - Leases link:presentationLink link:calculationLink link:definitionLink 9952169 - Disclosure - Convertible Preferred Stock and Stockholders’ Equity link:presentationLink link:calculationLink link:definitionLink 9952170 - Disclosure - Strategic License Agreements link:presentationLink link:calculationLink link:definitionLink 9952171 - Disclosure - Novation of Manufacturing Agreements link:presentationLink link:calculationLink link:definitionLink 9952172 - Disclosure - Stock-Based Compensation link:presentationLink link:calculationLink link:definitionLink 9952173 - Disclosure - Defined Contribution Plan link:presentationLink link:calculationLink link:definitionLink 9952174 - Disclosure - Restructuring Charges link:presentationLink link:calculationLink link:definitionLink 9952175 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 9952176 - Disclosure - Segment Reporting link:presentationLink link:calculationLink link:definitionLink 9952177 - Disclosure - Net Loss Per Share link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Fair Value Measurement (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Cash Equivalents and Marketable Securities (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Accrued and Other Current Liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Asset Acquisition (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Related Party Transactions (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - Stock-Based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Restructuring Charges (Tables) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Segment Reporting (Tables) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Net Loss Per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - The Company and Basis of Presentation (Details) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Summary of Significant Accounting Policies - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Summary of Significant Accounting Policies - Schedule of Useful Lives of Property and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Fair Value Measurements - Schedule of Financial Assets and Liabilities Measured at Fair Value on Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Fair Value Measurements - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Fair Value Measurements - Schedule of Changes in Forward Contract Liability (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Fair Value Measurements - Schedule of Significant Inputs used to Estimate the Fair Value of Derivative Liability (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Fair Value Measurements - Schedule of Changes in CVR Liability (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Cash Equivalents and Marketable Securities - Schedule of Estimated Fair Value of Cash Equivalents and Marketable Securities and the Gross Unrealized Gains and Losses (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Cash Equivalents and Marketable Securities - Schedule of Available-for-Sale Securities in an Unrealized Loss Position (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Cash Equivalents and Marketable Securities - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Cash Equivalents and Marketable Securities - Schedule of Contractual Maturities of Marketable Securities at Estimated Fair Value (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Property and Equipment, Net (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Accrued and Other Current Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Asset Acquisition - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Asset Acquisition - Schedule of Asset Acquisition Cost (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Paragon Agreement (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Licensing Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Related Party Transactions - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Related Party Transactions - Schedule of Expenses related to Related Party which were Settled in Cash (Details) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Related Party Transactions - Schedule of Related Party Accounts Payable (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Leases - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Leases - Schedule of Lease Cost (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - Convertible Preferred Stock and Stockholders’ Equity (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Strategic License Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 9955549 - Disclosure - Novation of Manufacturing Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 9955550 - Disclosure - Stock-Based Compensation - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955551 - Disclosure - Stock-Based Compensation - Schedule of Employee and Non-Employee Stock Option Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955552 - Disclosure - Stock-Based Compensation - Schedule of Employee Restricted Stock Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955553 - Disclosure - Stock-Based Compensation - Schedule of Stock-Based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955554 - Disclosure - Stock-Based Compensation - Schedule of Weighted-Average Assumptions Used in Calculating Fair Value of Awards (Details) link:presentationLink link:calculationLink link:definitionLink 9955555 - Disclosure - Defined Contribution Plan (Details) link:presentationLink link:calculationLink link:definitionLink 9955556 - Disclosure - Restructuring Charges - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955557 - Disclosure - Restructuring Charges - Schedule of Charges Related to the Restructuring Activities (Details) link:presentationLink link:calculationLink link:definitionLink 9955558 - Disclosure - Income Taxes - Schedule of (Loss) Income Before Income Tax Expense by Jurisdiction (Details) link:presentationLink link:calculationLink link:definitionLink 9955559 - Disclosure - Income Taxes - Schedule of Effective Income Tax Rate Reconciliation (Details) link:presentationLink link:calculationLink link:definitionLink 9955560 - Disclosure - Income Taxes - Schedule of Cash Income Taxes Paid (Details) link:presentationLink link:calculationLink link:definitionLink 9955561 - Disclosure - Income Taxes - Schedule of Components of Deferred Tax Assets and Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955562 - Disclosure - Income Taxes - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955563 - Disclosure - Segment Reporting - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955564 - Disclosure - Segment Reporting - Schedule of Significant Expenses Provided to the CODM on a Regular Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9955565 - Disclosure - Net Loss Per Share - Schedule of Computation of Basic and Diluted Net Loss Per Share (Details) link:presentationLink link:calculationLink link:definitionLink 9955566 - Disclosure - Net Loss Per Share - Schedule of Weighted-Average Equity Instruments Excluded from Calculation of Diluted Net Loss Per Share (Details) link:presentationLink link:calculationLink link:definitionLink