Governance Overview

*On December 4, 2025, the Spyre Board of Directors approved amendments to the Code of Business Conduct and Ethics to, among other minor changes, provide further detail regarding the company’s commitments to regulatory compliance and to maintaining and updating appropriate health and safety policies and add Section VI.

Overview of Committee Composition and Member Roles
Director Name	Audit Committee	Compensation Committee	Nominating and Corporate Governance Committee
Jeff Albers	Member of the Audit CommitteeAudit Committee	Chairperson of the Compensation CommitteeCompensation Committee
Peter Harwin			Member of the Nominating and Corporate Governance CommitteeNominating and Corporate Governance Committee
Michael Henderson	Member of the Audit CommitteeAudit Committee
Tomas Kiselak		Member of the Compensation CommitteeCompensation Committee
Mark McKenna
Sandra Milligan		Member of the Compensation CommitteeCompensation Committee	Chairperson of the Nominating and Corporate Governance CommitteeNominating and Corporate Governance Committee
Laurie Stelzer	Chairperson of the Audit CommitteeAudit Committee		Member of the Nominating and Corporate Governance CommitteeNominating and Corporate Governance Committee
Cameron Turtle